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Original Article
13 (
2
); 15-21

Hematological Findings In Various Hemoglobinopathies : A 3 Years Study At Tertiary Care Centre

Assistant Professor, Pathology Department, Dr. N.D. Desai Faculty of Medical Science & Research, Nadiad, Gujarat
Assistant Professor, Microbiology Department, Dr. N.D. Desai Faculty of Medical Science & Research, Nadiad, Gujarat
Associate Professor, Pathology Department, Dr. N.D. Desai Faculty of Medical Science & Research, Nadiad, Gujarat
Assistant Professor, Pathology Department, Dr. N.D. Desai Faculty of Medical Science & Research, Nadiad, Gujarat

*Corresponding Author: Dr. Anandkumar Aravindbhai Kanasagara Email: spl.naroda@yahoo.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Abstract

Introduction:

Hemoglobinopathies constitute a very important causative factor for anaemias of childhood. Two common hemoglobinopathies in India are Beta Thalassemia and Sickling disorders.

Objective:

The objective of this study is to know the hematological findings in various types of hemoglobinopathies & their distribution in various age and sex groups & communities, so that a solid conclusion can be made about screening of these hemoglobinopathies on high risk basis.

Material and Methods:

This is an observational study in 100 known patients of hemoglobinopathies who came to a tertiary care hospital from September 2015 to September 2018. Screening hematological tests for hemoglobinopathies such as complete blood count indices with Mentzer’s Index, Sickling test & peripheral blood smears were performed on all the patients and analyzed.

Results:

All the patients were having characteristic hematological findings. Among tile 100 patients there were 56 males and 44 females with age group ranging from 1 year to 32 years. 54% patients were having Beta Thalassemia, 40% patients were having Sickle cell disorder & 6% were having combination of both. Beta Thalassemia was most common in Bhanushali community and Sickle cell disorder was most common in Lohana community.

Conclusion:

Hemoglobinopathies can be diagnosed earlier wife meticulous use of simple & cost effective hematological screening tests in high risk age groups and communities in developing countries like India.

Keywords

Beta Thalassemia
Mentzer’s Index
Peripheral blood smear
Sickling Disorder
Sickling test

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